Malky Thomson's second string go into the Barclays Premier Reserves League South fixture having won just one of their previous four fixtures.
In the reverse fixture Blues came from a goal behind to earn a 2-1 victory against their Chelsea counterparts (their first win of the season) at Brentford FC's Griffin Park last November courtesy of goals from Jay O'Shea and Jake Jervis.
Blues Reserves are currently 6th in the league table having taken 15 points from their 14 games played whilst Chelsea's second string occupy 4th place with 19 points from their 15 games played.
Kick-off at St Andrews tonight is at 7pm.