Barry Ferguson, skipper Stephen Carr, Ben Foster, Roger Johnson and Liam Ridgewell were all rested for the 4-1 FA Cup win at Millwall on Saturday.
Midfielder Sebastian Larsson is included in the squad despite being given permission to speak to Newcastle over a possible move.
Striker Matt Derbyshire will be hoping his two goals at the New Den will bolster his chances of starting against Avram Grant's side.
Midfielder Lee Bowyer will again be unavailable as he completes a three-match suspension.
Source: PA
Source: PA