Terry Westley's bottom of the table side will be looking for their first win of the season against the current league leaders.
Blues' second string have lost 3 and drawn 2 of their first five Barclays Premier Reserves League South fixtures whereas tonights opponents are unbeaten with 4 wins and 2 draws from their first six fixtures.
The last time the two side's met at Reserve team level was back on 31st March 2008 when a Sam Williams goal gave the host's a 1-0 win at Villa Park.
In the reverse fixture at St Andrews that season Villa had gained a 2-0 success.
Kick-off at St Andrews tonight is at 7pm.
Blues Res: Joe Hart, Jacob Rowe, Gregory Vignal, Giovanny Espinoza, Franck Queudrue, Jordon Mutch, James O'Shea, Lee Carsley, Kevin Phillips, Robin Shroot, Gary McSheffrey. Subs: Jack Butland, Ashley Sammons, Jakub Hronec, Akwasi Asante, Jamie Dunphy.
Villa Res: Elliot Parish, Matthew Roome, Derrick Williams, Jonathan Hogg, Ciaran Clark, Nathan Baker, Marc Albrighton, Andreas Weimann, Nathan Delfouneso, Barry Bannan, Gary Gardner. Subs: William Grocott, Thomas Dau, Andras Stieber, Harry Forrester, Adam McGurk.