With five minutes of the second period played Wolves' midfielder Greg Halford doubled the home side's advantage.
Blues' best chance of the night fell to Robin Shroot in stoppage time but he failed to find the net when one-on-one with Wolves' substitute keeper Danny East.
Full time: Wolves Res 2 Blues Res 0
And so Blues' second string's poor start to the season continues. They are yet to record a win and remain firmly rooted at the foot of the table with just three points from their opening seven league games.
Wolves Res: Murray (East, 24), Foley, Malone, Ebanks Landell, Elokobi, Surman, Halford, Bennett, Hemmings, Spray, Jarvis. Subs: Rooneyy, Price, Metcalf, Parsonage.
Blues Res: Doyle, Jacob Rowe, Espinoza, Queudrue, Vignal (Luke Rowe, h/t), O'Shea, Mutch, Sammons (Asante, 55), Shroot, Ntambwe, Jervis. Subs: Butland, Dunphy, Kerr.